活性蛋白 > 其他 > Recombinant Human Membrane cofactor protein(CD46) (Active)
  • 產品名稱:

    Recombinant Human Membrane cofactor protein(CD46) (Active) IN STOCK

  • 貨期:
    3-7 工作日
  • uniprot號:
  • 貨號:
    CSB-MP004939HU
  • 規格:
    ¥2400
  • 圖像:


    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.



    Activity

    Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC50 of human CD46 protein is 0.8333-1.054 ng/ml.

  • 測活實驗手冊:
  • 分子結構:
  • 基因名稱:
    CD46
  • 別名:
    TLX (Trophoblast leukocyte common antigen) (CD46)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白描述:
    Partial
  • 分子量:
    61.6 kDa
  • 標簽信息:
    C-terminal FC-tagged
  • 來源:
    Mammalian cell
  • 純度:
    Greater than 92% as determined by SDS-PAGE.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
  • 內毒素:
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性:
    Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC50 of human CD46 protein is 0.8333-1.054 ng/ml.
  • 參考文獻:
    "CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation."
    Astier A., Trescol-Biemont M.-C., Azocar O., Lamouille B., Rabourdin-Combe C.
    J. Immunol. 164:6091-6095(2000)
  • 氨基酸序列:
    CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRD
    PLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT
    FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGK
    KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSA
    SGPRPTYKPPVSNY
  • 說明書:

    注:產品說明書可能有改進,請直接與CUSABIO產品專員聯系,索取最新版說明書!

  • 簡介:
    Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
    (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
    (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3.
    (Microbial infection) Acts as a receptor for cultured Measles virus.
    (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6.
    (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).
  • 蛋白儲存:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
  • 表達區域:
    35-328aa
  • 使用注意:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • 研究領域:
    Cancer